GHRP-6 vs Tesamorelin

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

GHRP-6

Growth Hormone Releasing Peptide 6 (GHRP-6) is one of the first synthetic growth hormone secretagogues discovered. It stimulates significant GH release but is known for causing intense hunger.

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Tesamorelin

Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH). It is FDA-approved under the brand name Egrifta for reducing excess abdominal fat in HIV-infected patients with lipodystrophy.

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Side-by-Side Comparison

Aspect	GHRP-6	Tesamorelin
Dose Range	100 mcg–300 mcg	2 mg
Frequency	3x daily	1x daily
Cycle Length	8–12 weeks	8–52 weeks
Route	subcutaneous	subcutaneous
Mechanism	Acts as a ghrelin mimetic, binding to the GHS-R receptor in the pituitary and hypothalamus. Stimulates GH release and also significantly increases appetite by mimicking ghrelin's hunger-signaling effects.	Stimulates the pituitary gland to produce and release growth hormone by binding to GHRH receptors. Increases IGF-1 levels which promotes lipolysis and reduces visceral adipose tissue.
Typical Dosage	Typical dosing: 100-300mcg administered 2-3 times daily. Often combined with GHRH peptides like CJC-1295 for synergistic effects.	FDA-approved dose: 2mg administered subcutaneously once daily. Research protocols may use various dosing schedules.
Administration	Subcutaneous injection. Best administered on an empty stomach. The strong hunger response can be beneficial for those trying to gain weight but challenging for cutting.	Subcutaneous injection into the abdomen. Rotate injection sites. Best administered at the same time daily, preferably in the evening.
Side Effects	Intense hunger (most notable effect), water retention, increased cortisol and prolactin, tingling/numbness, and potential blood pressure changes.	Common side effects include injection site reactions (erythema, pruritus), joint pain, peripheral edema, and muscle pain. May cause elevated blood glucose.
Best For	Muscle Growth Recovery & Healing	Muscle Growth Fat Loss