Follistatin vs GHRP-6

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Follistatin

Follistatin is a glycoprotein that inhibits myostatin, the protein responsible for limiting muscle growth. By blocking myostatin, follistatin can theoretically allow for increased muscle development beyond natural limits.

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GHRP-6

Growth Hormone Releasing Peptide 6 (GHRP-6) is one of the first synthetic growth hormone secretagogues discovered. It stimulates significant GH release but is known for causing intense hunger.

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Side-by-Side Comparison

Aspect	Follistatin	GHRP-6
Dose Range	50 mcg–100 mcg	100 mcg–300 mcg
Frequency	1x daily	3x daily
Cycle Length	2–4 weeks	8–12 weeks
Route	subcutaneous	subcutaneous
Mechanism	Binds to and neutralizes myostatin and activin, both of which are negative regulators of muscle mass. This removes the natural brake on muscle growth, allowing for enhanced hypertrophy.	Acts as a ghrelin mimetic, binding to the GHS-R receptor in the pituitary and hypothalamus. Stimulates GH release and also significantly increases appetite by mimicking ghrelin's hunger-signaling effects.
Typical Dosage	Research protocols typically use 100-300mcg daily, though optimal dosing is not well established. Gene therapy approaches have also been studied.	Typical dosing: 100-300mcg administered 2-3 times daily. Often combined with GHRH peptides like CJC-1295 for synergistic effects.
Administration	Subcutaneous injection. Different isoforms exist (FS344, FS315) with varying properties. Requires careful sourcing due to complexity.	Subcutaneous injection. Best administered on an empty stomach. The strong hunger response can be beneficial for those trying to gain weight but challenging for cutting.
Side Effects	Limited human data. Theoretical concerns about effects on other organs where activin signaling is important.	Intense hunger (most notable effect), water retention, increased cortisol and prolactin, tingling/numbness, and potential blood pressure changes.
Best For	Muscle Growth	Muscle Growth Recovery & Healing