FGL vs PE-22-28
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
FGL
FGL (FG Loop) is a synthetic peptide that mimics the neural cell adhesion molecule (NCAM) FG loop region. It promotes neuroplasticity and has shown cognitive-enhancing effects in research.
Full details →PE-22-28
PE-22-28 is a synthetic peptide fragment derived from research on the SAMP8 mouse model of accelerated aging. It has shown potential for enhancing memory and reducing cognitive decline.
Full details →Side-by-Side Comparison
| Aspect | FGL | PE-22-28 |
|---|---|---|
| Dose Range | 500 mcg–1 mg | 500 mcg–2 mg |
| Frequency | 1x daily | 1x daily |
| Cycle Length | 4–8 weeks | 1–2 weeks |
| Route | intranasal | subcutaneous |
| Mechanism | Binds to FGFR1 (fibroblast growth factor receptor 1) to activate downstream signaling cascades that promote neurite outgrowth, synaptic plasticity, and neuronal survival. | Derived from the protein that is deficient in SAMP8 mice. May work by inhibiting protein phosphatase 2A methylesterase, thereby affecting memory-related signaling pathways. |
| Typical Dosage | Research protocols have used subcutaneous doses ranging from 1-10mg. Intranasal administration also studied. Optimal dosing not established. | Research protocols vary. Intranasal dosing has been studied at various concentrations. Optimal human dosing not established. |
| Administration | Subcutaneous injection or intranasal administration. Research compound with limited human dosing data. | Intranasal administration preferred for CNS delivery. Research compound with limited human use data. |
| Side Effects | Limited human data available. Animal studies show good tolerability. | Very limited human data. Primarily studied in animal models for safety and efficacy. |
| Best For |
What They Have in Common
FGL, PE-22-28 are both commonly used for:
Key Differences
Unique to PE-22-28:
Which Has Stronger Evidence?
- Cognitive Performance: FGL has stronger research support.
| Goal | FGL | PE-22-28 |
|---|---|---|
| Cognitive Performance | medium | low |
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