CJC-1295 vs Ipamorelin vs Sermorelin
A three-way comparison to help you find the right peptide for your research goals.
CJC-1295
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce more growth hormone.
Full details →Ipamorelin
Ipamorelin is a selective growth hormone secretagogue that stimulates the release of growth hormone from the pituitary gland without significantly affecting cortisol or prolactin.
Full details →Sermorelin
Sermorelin is a synthetic analog of GHRH consisting of the first 29 amino acids of the natural hormone. It was previously FDA-approved for GH deficiency diagnosis and treatment in children.
Full details →Side-by-Side Comparison
| Aspect | CJC-1295 | Ipamorelin | Sermorelin |
|---|---|---|---|
| Mechanism | CJC-1295 binds to GHRH receptors in the pituitary, triggering increased production and release of growth hormone. The DAC (Drug Affinity Complex) version extends half-life significantly. | Acts as a ghrelin mimetic, binding to the ghrelin receptor (GHS-R) in the pituitary to stimulate GH release. Highly selective with minimal effect on other hormones. | Binds to GHRH receptors in the pituitary gland to stimulate natural GH production and release. Maintains the body's natural feedback mechanisms for GH regulation. |
| Typical Dosage | CJC-1295 DAC: 1-2mg weekly. CJC-1295 no DAC (Mod GRF 1-29): 100-300mcg 2-3 times daily. | Typical dosing ranges from 200-300mcg administered 2-3 times daily, often combined with CJC-1295. | Typical dosing: 200-500mcg administered once daily, usually before bed. Some protocols use twice daily dosing. |
| Administration | Subcutaneous injection, often combined with a GHRP like Ipamorelin for synergistic effects. Best administered before sleep or fasted. | Subcutaneous injection. Best results when administered fasted or before sleep. Often stacked with GHRH peptides. | Subcutaneous injection, preferably at bedtime to work with natural GH release patterns. Can be combined with GHRPs for synergistic effects. |
| Side Effects | Water retention, tingling in extremities, potential increase in cortisol and prolactin levels. | Generally well-tolerated. May cause mild headaches, lightheadedness, or increased hunger initially. | Generally well-tolerated. May cause injection site reactions, headache, flushing, or dizziness. Less side effects than direct GH administration. |
| Best For |
What They Have in Common
CJC-1295, Ipamorelin, Sermorelin are all commonly used for:
Key Differences
Unique to Ipamorelin:
Unique to Sermorelin:
Detailed Analysis
Commonalities
Both CJC-1295 and Ipamorelin are commonly used for Muscle Growth, Fat Loss, Sleep Quality.
Which Should You Choose?
Ipamorelin has stronger evidence for Sleep Quality.
Commonalities
Both CJC-1295 and Sermorelin are commonly used for Muscle Growth, Fat Loss, Sleep Quality.
Which Should You Choose?
CJC-1295 has stronger evidence for Muscle Growth, Fat Loss.
Commonalities
Both Ipamorelin and Sermorelin are commonly used for Muscle Growth, Fat Loss, Recovery & Healing, Sleep Quality.
Which Should You Choose?
Ipamorelin has stronger evidence for Muscle Growth, Fat Loss, Sleep Quality.