Melanotan I
Melanotan I (afamelanotide) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH). It is FDA-approved as Scenesse for erythropoietic protoporphyria (EPP), a rare genetic disorder causing severe sun sensitivity.
Mechanism of Action
Binds to melanocortin 1 receptors (MC1R) on melanocytes, stimulating eumelanin production. This increases skin pigmentation and provides photoprotection without UV exposure.
Dosage Overview
Dose Range
250 mcg – 500 mcg
Route
subcutaneous
Frequency
1x daily
Cycle Length
1–4 weeks
Reconstitution
Typical Dosage (Research)
Clinical: 16mg implant every 2 months. Research protocols for tanning typically use 0.5-1mg daily for loading, then maintenance dosing.
FDA-approved form is a subcutaneous implant. Research use involves subcutaneous injection. Often combined with minimal UV exposure to enhance results.
Considerations for Men & Women
Women: Afamelanotide (Scenesse) is FDA-approved for EPP. Produces gradual tanning without UV. Less likely to cause sexual side effects compared to Melanotan II. Contraindicated during pregnancy.
Men: Same tanning effects. Minimal sexual side effects unlike MT-II. No sex-specific dose adjustments. Same subcutaneous implant protocol in clinical use.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 5,000 mcg/ml
Volume to inject: 0.05 ml
Syringe units (U-100): 5.0 units
Pre-filled with Melanotan I defaults. Adjust values as needed.
Side Effects & Risks
Nausea (especially initially), facial flushing, fatigue, headache, and darkening of existing moles or freckles.
May darken existing moles making melanoma detection difficult. Not recommended for those with history of melanoma. Long-term effects on melanocytes not fully characterized.
Who Uses Melanotan I
EPP patients (approved use), those seeking sunless tanning, fair-skinned individuals wanting photoprotection.
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