Syn-Ake vs Leuphasyl
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Syn-Ake
Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate) is a synthetic tripeptide that mimics the effect of Waglerin-1, a peptide found in Temple Viper venom. It's used in cosmetics for anti-wrinkle effects.
Full details →Leuphasyl
Leuphasyl (Pentapeptide-18) is a cosmetic peptide that reduces muscle tension through a mechanism similar to enkephalins. Often combined with Syn-Ake for enhanced anti-wrinkle effects.
Full details →Side-by-Side Comparison
| Aspect | Syn-Ake | Leuphasyl |
|---|---|---|
| Mechanism | Acts as a competitive antagonist at the nicotinic acetylcholine receptor, reducing muscle contractions similar to Botox but through a different mechanism. Provides muscle-relaxing effects when applied topically. | Mimics enkephalin and binds to enkephalin receptors on muscle cells, reducing acetylcholine release and thereby decreasing muscle contraction intensity. |
| Typical Dosage | Topical: 1-4% concentration in serums or creams. Applied 1-2 times daily to target areas like forehead and crow's feet. | Topical: 3-8% concentration in serums. Often used in combination products with other muscle-relaxing peptides. |
| Administration | Topical application only. Should be applied to clean skin. Often combined with other anti-aging peptides for synergistic effects. | Topical application to expression lines. Best results with consistent twice-daily use over 8+ weeks. |
| Side Effects | Generally well-tolerated topically. Rare reports of mild skin irritation or sensitivity. | Very well-tolerated topically. No significant adverse effects reported at cosmetic concentrations. |
| Best For |
What They Have in Common
Both Syn-Ake and Leuphasyl are commonly used for: