SS-31 (Elamipretide) vs TB-500

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

SS-31 (Elamipretide)

SS-31, also known as Elamipretide or Bendavia, is a mitochondria-targeted tetrapeptide. It has been studied extensively for mitochondrial diseases, heart failure, and age-related decline in mitochondrial function.

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TB-500

Thymosin Beta-4 (TB-500) is a naturally occurring peptide present in almost all human and animal cells. It plays a crucial role in tissue repair and regeneration.

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Side-by-Side Comparison

Aspect	SS-31 (Elamipretide)	TB-500
Dose Range	20 mg–40 mg	2 mg–2.5 mg
Frequency	1x daily	Less than daily
Cycle Length	4–12 weeks	4–8 weeks
Route	subcutaneous	subcutaneous
Mechanism	Concentrates in the inner mitochondrial membrane where it binds to cardiolipin, stabilizing electron transport chain function, reducing reactive oxygen species, and improving ATP production efficiency.	TB-500 promotes cell migration and differentiation, regulates actin (a cell-building protein), and reduces inflammation. It supports the formation of new blood vessels and wound healing.
Typical Dosage	Clinical trials have used IV infusions of 0.25mg/kg for acute conditions. Subcutaneous dosing protocols for research use typically range from 1-5mg daily.	Research protocols typically use 2-2.5mg twice weekly during the loading phase, followed by maintenance dosing of 2mg every 2 weeks.
Administration	Can be administered IV or subcutaneously. Most clinical research has used IV administration for cardiac conditions.	Administered via subcutaneous or intramuscular injection. Some protocols suggest injection near injury sites.
Side Effects	Generally well-tolerated. Clinical trials reported injection site reactions and occasional headache.	May cause temporary fatigue, headache, or localized irritation at injection sites.
Best For	Recovery & Healing Anti-Aging & Longevity	Muscle Growth Recovery & Healing