SNAP-8 vs SHLP2
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
SNAP-8
SNAP-8 (Acetyl Octapeptide-3) is a cosmetic peptide that reduces the appearance of wrinkles by modulating muscle contraction. It is often called 'topical Botox' though it works through a different mechanism.
Full details →SHLP2
SHLP2 (Small Humanin-Like Peptide 2) is a mitochondrial-derived peptide similar to humanin. It has shown insulin-sensitizing and cytoprotective effects in research, with potential metabolic benefits.
Full details →Side-by-Side Comparison
| Aspect | SNAP-8 | SHLP2 |
|---|---|---|
| Mechanism | Mimics the N-terminal end of SNAP-25, competing with native SNAP-25 for position in the SNARE complex. This reduces neurotransmitter release at the neuromuscular junction, decreasing muscle contraction. | Enhances insulin sensitivity and glucose uptake. Provides cytoprotective effects similar to humanin. May act through similar but distinct receptor pathways. |
| Typical Dosage | Topical: 3-10% concentration in serums or creams, applied 1-2 times daily to target areas (forehead, crow's feet, etc.). | Research compound with doses in the microgram to low milligram range studied in animal models. Human dosing not established. |
| Administration | Topical application only. Should be applied to clean skin. Often formulated with penetration enhancers for better absorption. | Subcutaneous or intraperitoneal injection in research settings. Various SHLP analogs (1-6) have different properties. |
| Side Effects | Generally well-tolerated topically. Rare reports of mild skin irritation. No systemic effects at cosmetic doses. | Limited data. Animal studies suggest good tolerability. May affect glucose metabolism. |
| Best For |