PE-22-28 vs Selank
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
PE-22-28
PE-22-28 is a synthetic peptide fragment derived from research on the SAMP8 mouse model of accelerated aging. It has shown potential for enhancing memory and reducing cognitive decline.
Full details →Selank
Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin. Developed in Russia for anxiety and cognitive enhancement.
Full details →Side-by-Side Comparison
| Aspect | PE-22-28 | Selank |
|---|---|---|
| Dose Range | 500 mcg–2 mg | 300 mcg–900 mcg |
| Frequency | 1x daily | 2x daily |
| Cycle Length | 1–2 weeks | 2–4 weeks |
| Route | subcutaneous | intranasal |
| Mechanism | Derived from the protein that is deficient in SAMP8 mice. May work by inhibiting protein phosphatase 2A methylesterase, thereby affecting memory-related signaling pathways. | Modulates the expression of brain-derived neurotrophic factor (BDNF) and affects serotonin and norepinephrine systems. Has immunomodulatory and anxiolytic properties. |
| Typical Dosage | Research protocols vary. Intranasal dosing has been studied at various concentrations. Optimal human dosing not established. | Intranasal administration: 250-500mcg 2-3 times daily. Subcutaneous: 250-500mcg daily. |
| Administration | Intranasal administration preferred for CNS delivery. Research compound with limited human use data. | Most commonly administered intranasally for cognitive effects. Can also be injected subcutaneously. |
| Side Effects | Very limited human data. Primarily studied in animal models for safety and efficacy. | Generally well-tolerated. Some users report mild fatigue or nasal irritation with intranasal use. |
| Best For |
What They Have in Common
PE-22-28, Selank are both commonly used for:
Key Differences
Unique to PE-22-28:
Which Has Stronger Evidence?
- Cognitive Performance: Selank has stronger research support.
| Goal | PE-22-28 | Selank |
|---|---|---|
| Cognitive Performance | low | high |
Key Studies
Selank
- Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Bulletin of experimental biology and medicine, 2022
- The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
Current reviews in clinical and experimental pharmacology, 2021
- Functional Connectomic Approach to Studying Selank and Semax Effects.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2020
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