Noopept vs Selank

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Noopept

Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a peptide-derived nootropic developed in Russia. While technically a dipeptide prodrug rather than a true peptide, it's often discussed alongside peptide nootropics.

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Selank

Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin. Developed in Russia for anxiety and cognitive enhancement.

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Side-by-Side Comparison

Aspect	Noopept	Selank
Dose Range	10 mg–30 mg	300 mcg–900 mcg
Frequency	2x daily	2x daily
Cycle Length	4–6 weeks	2–4 weeks
Route	oral	intranasal
Mechanism	Metabolized to cycloprolylglycine which modulates AMPA and NMDA receptors, increases NGF and BDNF expression, and provides neuroprotective effects through antioxidant mechanisms.	Modulates the expression of brain-derived neurotrophic factor (BDNF) and affects serotonin and norepinephrine systems. Has immunomodulatory and anxiolytic properties.
Typical Dosage	Oral: 10-30mg daily, typically divided into 2-3 doses. Sublingual use may enhance absorption. Some users go higher but effects may plateau.	Intranasal administration: 250-500mcg 2-3 times daily. Subcutaneous: 250-500mcg daily.
Administration	Oral or sublingual administration. Unlike most peptides, it's orally bioavailable. Can be taken with or without food.	Most commonly administered intranasally for cognitive effects. Can also be injected subcutaneously.
Side Effects	Headache (often from choline depletion), irritability, insomnia if taken late, and occasional brain fog during initial use.	Generally well-tolerated. Some users report mild fatigue or nasal irritation with intranasal use.
Best For	Cognitive Performance	Cognitive Performance