MOTS-c vs CJC-1295
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide that plays a key role in metabolic regulation and has emerged as a significant longevity research target.
Full details →CJC-1295
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce more growth hormone.
Full details →Side-by-Side Comparison
| Aspect | MOTS-c | CJC-1295 |
|---|---|---|
| Mechanism | Activates AMPK pathway, enhances glucose uptake in skeletal muscle, improves insulin sensitivity, and regulates mitochondrial function. Acts as a metabolic hormone affecting whole-body energy homeostasis. | CJC-1295 binds to GHRH receptors in the pituitary, triggering increased production and release of growth hormone. The DAC (Drug Affinity Complex) version extends half-life significantly. |
| Typical Dosage | Research protocols typically use 5-10mg administered subcutaneously several times per week. Optimal dosing not yet established. | CJC-1295 DAC: 1-2mg weekly. CJC-1295 no DAC (Mod GRF 1-29): 100-300mcg 2-3 times daily. |
| Administration | Subcutaneous injection. Often combined with exercise protocols as it enhances exercise capacity and metabolic adaptation. | Subcutaneous injection, often combined with a GHRP like Ipamorelin for synergistic effects. Best administered before sleep or fasted. |
| Side Effects | Limited human data. Animal studies show good tolerability. May affect energy levels and exercise performance. | Water retention, tingling in extremities, potential increase in cortisol and prolactin levels. |
| Best For |
What They Have in Common
Both MOTS-c and CJC-1295 are commonly used for:
Key Differences
Unique to MOTS-c:
Unique to CJC-1295:
Detailed Analysis
Both CJC-1295 and MOTS-c are commonly used for Muscle Growth, Fat Loss.
Which Should You Choose?
CJC-1295 has stronger evidence for Muscle Growth, Fat Loss.