Leuphasyl vs Syn-Ake
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Leuphasyl
Leuphasyl (Pentapeptide-18) is a cosmetic peptide that reduces muscle tension through a mechanism similar to enkephalins. Often combined with Syn-Ake for enhanced anti-wrinkle effects.
Full details →Syn-Ake
Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate) is a synthetic tripeptide that mimics the effect of Waglerin-1, a peptide found in Temple Viper venom. It's used in cosmetics for anti-wrinkle effects.
Full details →Side-by-Side Comparison
| Aspect | Leuphasyl | Syn-Ake |
|---|---|---|
| Dose Range | 200 mcg–500 mcg | 200 mcg–500 mcg |
| Frequency | 2x daily | 2x daily |
| Cycle Length | 4–8 weeks | 4–8 weeks |
| Route | topical | topical |
| Mechanism | Mimics enkephalin and binds to enkephalin receptors on muscle cells, reducing acetylcholine release and thereby decreasing muscle contraction intensity. | Acts as a competitive antagonist at the nicotinic acetylcholine receptor, reducing muscle contractions similar to Botox but through a different mechanism. Provides muscle-relaxing effects when applied topically. |
| Typical Dosage | Topical: 3-8% concentration in serums. Often used in combination products with other muscle-relaxing peptides. | Topical: 1-4% concentration in serums or creams. Applied 1-2 times daily to target areas like forehead and crow's feet. |
| Administration | Topical application to expression lines. Best results with consistent twice-daily use over 8+ weeks. | Topical application only. Should be applied to clean skin. Often combined with other anti-aging peptides for synergistic effects. |
| Side Effects | Very well-tolerated topically. No significant adverse effects reported at cosmetic concentrations. | Generally well-tolerated topically. Rare reports of mild skin irritation or sensitivity. |
| Best For |
What They Have in Common
Leuphasyl, Syn-Ake are both commonly used for:
Which Has Stronger Evidence?
| Goal | Leuphasyl | Syn-Ake |
|---|---|---|
| Skin Health & Aesthetics | medium | medium |
Key Studies
Leuphasyl
- Integrative In Silico and In Vitro Evaluation of Vialox and Leuphasyl Pentapeptides for Antiaging Applications.
Chemistry & biodiversity, 2026
Syn-Ake
- Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests.
Journal of biomolecular structure & dynamics, 2024
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