Leuphasyl vs Palmitoyl Tetrapeptide-7
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Leuphasyl
Leuphasyl (Pentapeptide-18) is a cosmetic peptide that reduces muscle tension through a mechanism similar to enkephalins. Often combined with Syn-Ake for enhanced anti-wrinkle effects.
Full details →Palmitoyl Tetrapeptide-7
Palmitoyl Tetrapeptide-7 is an anti-inflammatory peptide that reduces IL-6 secretion. Combined with Palmitoyl Tripeptide-1, it forms Matrixyl 3000, addressing both collagen production and inflammation.
Full details →Side-by-Side Comparison
| Aspect | Leuphasyl | Palmitoyl Tetrapeptide-7 |
|---|---|---|
| Dose Range | 200 mcg–500 mcg | 500 mcg–2 mg |
| Frequency | 2x daily | 2x daily |
| Cycle Length | 4–8 weeks | 4–12 weeks |
| Route | topical | topical |
| Mechanism | Mimics enkephalin and binds to enkephalin receptors on muscle cells, reducing acetylcholine release and thereby decreasing muscle contraction intensity. | Suppresses interleukin-6 (IL-6) production, reducing inflammation that contributes to skin aging. The anti-inflammatory effect complements collagen-stimulating peptides. |
| Typical Dosage | Topical: 3-8% concentration in serums. Often used in combination products with other muscle-relaxing peptides. | Topical: Usually combined with Palmitoyl Tripeptide-1 at similar concentrations (2-4%) in the Matrixyl 3000 complex. |
| Administration | Topical application to expression lines. Best results with consistent twice-daily use over 8+ weeks. | Topical application with other anti-aging actives. The palmitoyl group enhances delivery into the skin. |
| Side Effects | Very well-tolerated topically. No significant adverse effects reported at cosmetic concentrations. | Excellent tolerability profile. Anti-inflammatory properties may actually soothe sensitive skin. |
| Best For |
What They Have in Common
Leuphasyl, Palmitoyl Tetrapeptide-7 are both commonly used for:
Which Has Stronger Evidence?
- Skin Health & Aesthetics: Palmitoyl Tetrapeptide-7 has stronger research support.
| Goal | Leuphasyl | Palmitoyl Tetrapeptide-7 |
|---|---|---|
| Skin Health & Aesthetics | medium | high |
Key Studies
Leuphasyl
- Integrative In Silico and In Vitro Evaluation of Vialox and Leuphasyl Pentapeptides for Antiaging Applications.
Chemistry & biodiversity, 2026
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