Hexarelin vs Tesamorelin

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Hexarelin

Hexarelin is a potent synthetic hexapeptide growth hormone secretagogue. It provides the strongest GH release among GHRPs but is associated with rapid desensitization of receptors.

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Tesamorelin

Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH). It is FDA-approved under the brand name Egrifta for reducing excess abdominal fat in HIV-infected patients with lipodystrophy.

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Side-by-Side Comparison

Aspect	Hexarelin	Tesamorelin
Dose Range	100 mcg–300 mcg	2 mg
Frequency	2x daily	1x daily
Cycle Length	8–12 weeks	8–52 weeks
Route	subcutaneous	subcutaneous
Mechanism	Acts as a ghrelin mimetic with high potency at the GHS receptor. Provides powerful GH release but receptor desensitization occurs faster than with other GHRPs, requiring cycling.	Stimulates the pituitary gland to produce and release growth hormone by binding to GHRH receptors. Increases IGF-1 levels which promotes lipolysis and reduces visceral adipose tissue.
Typical Dosage	Typical dosing: 100-200mcg administered 2-3 times daily for 4-6 weeks, followed by an equal off period to allow receptor resensitization.	FDA-approved dose: 2mg administered subcutaneously once daily. Research protocols may use various dosing schedules.
Administration	Subcutaneous injection. Cycling is essential to maintain effectiveness. Often used in short bursts rather than continuous protocols.	Subcutaneous injection into the abdomen. Rotate injection sites. Best administered at the same time daily, preferably in the evening.
Side Effects	Water retention, cortisol and prolactin increase, hunger (moderate), tingling, and potential blood pressure effects.	Common side effects include injection site reactions (erythema, pruritus), joint pain, peripheral edema, and muscle pain. May cause elevated blood glucose.
Best For	Muscle Growth Recovery & Healing	Muscle Growth Fat Loss