Hexarelin vs NA-Semax Amidate

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Hexarelin

Hexarelin is a potent synthetic hexapeptide growth hormone secretagogue. It provides the strongest GH release among GHRPs but is associated with rapid desensitization of receptors.

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NA-Semax Amidate

NA-Semax Amidate (N-Acetyl Semax Amidate) is a modified version of Semax with enhanced stability and potency. Also known as NASA, it provides stronger and longer-lasting nootropic effects than standard Semax.

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Side-by-Side Comparison

AspectHexarelinNA-Semax Amidate
MechanismActs as a ghrelin mimetic with high potency at the GHS receptor. Provides powerful GH release but receptor desensitization occurs faster than with other GHRPs, requiring cycling.Maintains Semax's core actions on BDNF, NGF, and monoamine systems with improved pharmacokinetics. The modifications enhance CNS penetration and extend duration of action.
Typical DosageTypical dosing: 100-200mcg administered 2-3 times daily for 4-6 weeks, followed by an equal off period to allow receptor resensitization.Intranasal: 100-600mcg 1-2 times daily. Start with lower doses as it's more potent than standard Semax.
AdministrationSubcutaneous injection. Cycling is essential to maintain effectiveness. Often used in short bursts rather than continuous protocols.Intranasal spray is most common. Can be used sublingually. More stable than standard Semax in solution.
Side EffectsWater retention, cortisol and prolactin increase, hunger (moderate), tingling, and potential blood pressure effects.May cause irritability, hair shedding (rare), or overstimulation at high doses. Generally well-tolerated.
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Key Differences

Unique to Hexarelin:

Unique to NA-Semax Amidate:

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