Hexarelin vs Epithalamin

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Hexarelin

Hexarelin is a potent synthetic hexapeptide growth hormone secretagogue. It provides the strongest GH release among GHRPs but is associated with rapid desensitization of receptors.

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Epithalamin

Epithalamin is a natural peptide extract from the pineal gland. It is the precursor compound from which the synthetic Epitalon was derived. Known for anti-aging and telomerase-activating properties.

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Side-by-Side Comparison

AspectHexarelinEpithalamin
MechanismActs as a ghrelin mimetic with high potency at the GHS receptor. Provides powerful GH release but receptor desensitization occurs faster than with other GHRPs, requiring cycling.Similar to Epitalon, it stimulates telomerase production and may help maintain telomere length. Also regulates melatonin synthesis and circadian rhythms.
Typical DosageTypical dosing: 100-200mcg administered 2-3 times daily for 4-6 weeks, followed by an equal off period to allow receptor resensitization.Research dosing: 10-20mg daily for 10-20 day cycles. Often administered 1-3 times per year in long-term protocols.
AdministrationSubcutaneous injection. Cycling is essential to maintain effectiveness. Often used in short bursts rather than continuous protocols.Intramuscular or subcutaneous injection. Natural extract may have more variable composition than synthetic Epitalon.
Side EffectsWater retention, cortisol and prolactin increase, hunger (moderate), tingling, and potential blood pressure effects.Generally well-tolerated. May affect sleep patterns. Less characterized than synthetic Epitalon.
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Key Differences

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