GHRP-2 vs Syn-Ake
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
GHRP-2
Growth Hormone Releasing Peptide 2 (GHRP-2) is considered one of the most potent GHRPs available. It provides strong GH release with moderate hunger increase compared to GHRP-6.
Full details →Syn-Ake
Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate) is a synthetic tripeptide that mimics the effect of Waglerin-1, a peptide found in Temple Viper venom. It's used in cosmetics for anti-wrinkle effects.
Full details →Side-by-Side Comparison
| Aspect | GHRP-2 | Syn-Ake |
|---|---|---|
| Dose Range | 100 mcg–300 mcg | 200 mcg–500 mcg |
| Frequency | 3x daily | 2x daily |
| Cycle Length | 8–12 weeks | 4–8 weeks |
| Route | subcutaneous | topical |
| Mechanism | Binds to the ghrelin receptor (GHS-R) to stimulate GH release from the pituitary. Also has some direct effects on the hypothalamus. Causes less appetite increase than GHRP-6. | Acts as a competitive antagonist at the nicotinic acetylcholine receptor, reducing muscle contractions similar to Botox but through a different mechanism. Provides muscle-relaxing effects when applied topically. |
| Typical Dosage | Typical dosing: 100-300mcg administered 2-3 times daily. Often stacked with GHRH peptides for enhanced GH release. | Topical: 1-4% concentration in serums or creams. Applied 1-2 times daily to target areas like forehead and crow's feet. |
| Administration | Subcutaneous injection on an empty stomach. Can be used at bedtime to enhance natural GH pulse during sleep. | Topical application only. Should be applied to clean skin. Often combined with other anti-aging peptides for synergistic effects. |
| Side Effects | Moderate hunger increase, water retention, potential prolactin and cortisol elevation (less than GHRP-6), tingling sensations. | Generally well-tolerated topically. Rare reports of mild skin irritation or sensitivity. |
| Best For |
Key Differences
Unique to GHRP-2:
Unique to Syn-Ake:
Key Studies
GHRP-2
- On the road of dried blood spot sampling for antidoping tests: Detection of GHRP-2 abuse.
Drug testing and analysis, 2021
- Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation.
PloS one, 2016
- Ghrelin receptor agonist, GHRP-2, produces antinociceptive effects at the supraspinal level via the opioid receptor in mice.
Peptides, 2014
Syn-Ake
- Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests.
Journal of biomolecular structure & dynamics, 2024
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