GHK-Cu (Copper Peptide) vs TB-500

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

GHK-Cu (Copper Peptide)

GHK-Cu is a naturally occurring copper peptide found in human plasma, saliva, and urine. It plays important roles in wound healing, tissue repair, and has shown anti-aging properties in research.

Full details →

TB-500

Thymosin Beta-4 (TB-500) is a naturally occurring peptide present in almost all human and animal cells. It plays a crucial role in tissue repair and regeneration.

Full details →

Side-by-Side Comparison

Aspect	GHK-Cu (Copper Peptide)	TB-500
Dose Range	1 mg–2 mg	2 mg–2.5 mg
Frequency	1x daily	Less than daily
Cycle Length	4–8 weeks	4–8 weeks
Route	subcutaneous	subcutaneous
Mechanism	Attracts immune cells and fibroblasts to wound sites, stimulates collagen and glycosaminoglycan synthesis, promotes angiogenesis, and has antioxidant effects. Modulates gene expression related to tissue repair.	TB-500 promotes cell migration and differentiation, regulates actin (a cell-building protein), and reduces inflammation. It supports the formation of new blood vessels and wound healing.
Typical Dosage	Topical: Applied as serum or cream 1-2 times daily. Injectable: 1-2mg daily for research purposes. Microneedling protocols often use 0.5-1%.	Research protocols typically use 2-2.5mg twice weekly during the loading phase, followed by maintenance dosing of 2mg every 2 weeks.
Administration	Most commonly used topically for skin applications. Can be injected subcutaneously for systemic effects. Often combined with microneedling for enhanced skin penetration.	Administered via subcutaneous or intramuscular injection. Some protocols suggest injection near injury sites.
Side Effects	Topical use is generally well-tolerated. May cause temporary skin irritation or redness in sensitive individuals. Injectable use may cause injection site reactions.	May cause temporary fatigue, headache, or localized irritation at injection sites.
Best For	Recovery & Healing	Muscle Growth Recovery & Healing