FGL vs Selank
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
FGL
FGL (FG Loop) is a synthetic peptide that mimics the neural cell adhesion molecule (NCAM) FG loop region. It promotes neuroplasticity and has shown cognitive-enhancing effects in research.
Full details →Selank
Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin. Developed in Russia for anxiety and cognitive enhancement.
Full details →Side-by-Side Comparison
| Aspect | FGL | Selank |
|---|---|---|
| Dose Range | 500 mcg–1 mg | 300 mcg–900 mcg |
| Frequency | 1x daily | 2x daily |
| Cycle Length | 4–8 weeks | 2–4 weeks |
| Route | intranasal | intranasal |
| Mechanism | Binds to FGFR1 (fibroblast growth factor receptor 1) to activate downstream signaling cascades that promote neurite outgrowth, synaptic plasticity, and neuronal survival. | Modulates the expression of brain-derived neurotrophic factor (BDNF) and affects serotonin and norepinephrine systems. Has immunomodulatory and anxiolytic properties. |
| Typical Dosage | Research protocols have used subcutaneous doses ranging from 1-10mg. Intranasal administration also studied. Optimal dosing not established. | Intranasal administration: 250-500mcg 2-3 times daily. Subcutaneous: 250-500mcg daily. |
| Administration | Subcutaneous injection or intranasal administration. Research compound with limited human dosing data. | Most commonly administered intranasally for cognitive effects. Can also be injected subcutaneously. |
| Side Effects | Limited human data available. Animal studies show good tolerability. | Generally well-tolerated. Some users report mild fatigue or nasal irritation with intranasal use. |
| Best For |
What They Have in Common
FGL, Selank are both commonly used for:
Which Has Stronger Evidence?
- Cognitive Performance: Selank has stronger research support.
| Goal | FGL | Selank |
|---|---|---|
| Cognitive Performance | medium | high |
Key Studies
Selank
- Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Bulletin of experimental biology and medicine, 2022
- The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
Current reviews in clinical and experimental pharmacology, 2021
- Functional Connectomic Approach to Studying Selank and Semax Effects.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2020
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