Epithalamin vs Humanin
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Epithalamin
Epithalamin is a natural peptide extract from the pineal gland. It is the precursor compound from which the synthetic Epitalon was derived. Known for anti-aging and telomerase-activating properties.
Full details →Humanin
Humanin is a mitochondrial-derived peptide with potent cytoprotective effects. Discovered in 2001, it has shown promise in protecting against age-related diseases including Alzheimer's, cardiovascular disease, and diabetes.
Full details →Side-by-Side Comparison
| Aspect | Epithalamin | Humanin |
|---|---|---|
| Mechanism | Similar to Epitalon, it stimulates telomerase production and may help maintain telomere length. Also regulates melatonin synthesis and circadian rhythms. | Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 signaling and enhances cellular survival under stress. Protects mitochondrial function and reduces oxidative stress. |
| Typical Dosage | Research dosing: 10-20mg daily for 10-20 day cycles. Often administered 1-3 times per year in long-term protocols. | Research protocols vary widely. Studies have used doses from micrograms to milligrams depending on the analog and route. HNG (S14G-Humanin) is a more potent analog. |
| Administration | Intramuscular or subcutaneous injection. Natural extract may have more variable composition than synthetic Epitalon. | Subcutaneous or intraperitoneal injection in research. Various analogs exist with different potencies and stabilities. |
| Side Effects | Generally well-tolerated. May affect sleep patterns. Less characterized than synthetic Epitalon. | Limited human data. Generally well-tolerated in animal studies. May affect glucose metabolism. |
| Best For |
What They Have in Common
Both Epithalamin and Humanin are commonly used for: