Epitalon vs SHLP2
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Epitalon
Epitalon (Epithalon) is a synthetic tetrapeptide based on the natural peptide epithalamin, produced by the pineal gland. It is primarily studied for its effects on telomerase activation.
Full details →SHLP2
SHLP2 (Small Humanin-Like Peptide 2) is a mitochondrial-derived peptide similar to humanin. It has shown insulin-sensitizing and cytoprotective effects in research, with potential metabolic benefits.
Full details →Side-by-Side Comparison
| Aspect | Epitalon | SHLP2 |
|---|---|---|
| Dose Range | 5 mg–10 mg | 1 mg–5 mg |
| Frequency | 1x daily | 1x daily |
| Cycle Length | 2–3 weeks | 4–8 weeks |
| Route | subcutaneous | subcutaneous |
| Mechanism | Stimulates telomerase production, which can lengthen telomeres on DNA strands. May also regulate melatonin production and circadian rhythms. | Enhances insulin sensitivity and glucose uptake. Provides cytoprotective effects similar to humanin. May act through similar but distinct receptor pathways. |
| Typical Dosage | Typical protocols: 5-10mg daily for 10-20 days, repeated 2-3 times per year. | Research compound with doses in the microgram to low milligram range studied in animal models. Human dosing not established. |
| Administration | Subcutaneous or intramuscular injection. Usually administered in cycles rather than continuously. | Subcutaneous or intraperitoneal injection in research settings. Various SHLP analogs (1-6) have different properties. |
| Side Effects | Generally well-tolerated. May affect sleep patterns initially. | Limited data. Animal studies suggest good tolerability. May affect glucose metabolism. |
| Best For |
Key Differences
Unique to Epitalon:
Unique to SHLP2:
Key Studies
Epitalon
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
International journal of molecular sciences, 2025
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Biogerontology, 2025
- The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Stem cell reviews and reports, 2025
SHLP2
- Mitochondrial Peptide SHLP2 Limits Poly(I: C)-Induced Alveolar Epithelial Injury by Modulating Redox, Apoptotic, Inflammatory, and Inflammasome Responses.
Cytotechnology, 2026
- SHLP2 restores pre-osteoblastic cells against oxidative stress-induced inflammaging.
Scientific reports, 2025
- SHLP2 alleviates allergic asthma by inhibiting ETV5/GSDMD signaling pathway-mediated pyroptosis.
Cellular signalling, 2025
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