Epitalon vs Leuphasyl

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Epitalon

Epitalon (Epithalon) is a synthetic tetrapeptide based on the natural peptide epithalamin, produced by the pineal gland. It is primarily studied for its effects on telomerase activation.

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Leuphasyl

Leuphasyl (Pentapeptide-18) is a cosmetic peptide that reduces muscle tension through a mechanism similar to enkephalins. Often combined with Syn-Ake for enhanced anti-wrinkle effects.

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Side-by-Side Comparison

AspectEpitalonLeuphasyl
MechanismStimulates telomerase production, which can lengthen telomeres on DNA strands. May also regulate melatonin production and circadian rhythms.Mimics enkephalin and binds to enkephalin receptors on muscle cells, reducing acetylcholine release and thereby decreasing muscle contraction intensity.
Typical DosageTypical protocols: 5-10mg daily for 10-20 days, repeated 2-3 times per year.Topical: 3-8% concentration in serums. Often used in combination products with other muscle-relaxing peptides.
AdministrationSubcutaneous or intramuscular injection. Usually administered in cycles rather than continuously.Topical application to expression lines. Best results with consistent twice-daily use over 8+ weeks.
Side EffectsGenerally well-tolerated. May affect sleep patterns initially.Very well-tolerated topically. No significant adverse effects reported at cosmetic concentrations.
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Key Differences

Unique to Epitalon:

Unique to Leuphasyl:

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