Cortexin vs Ipamorelin

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Cortexin

Cortexin is a polypeptide complex derived from pig brain cortex, used clinically in Russia and Eastern Europe for neurological conditions including stroke recovery, traumatic brain injury, and cognitive decline.

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Ipamorelin

Ipamorelin is a selective growth hormone secretagogue that stimulates the release of growth hormone from the pituitary gland without significantly affecting cortisol or prolactin.

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Side-by-Side Comparison

Aspect	Cortexin	Ipamorelin
Dose Range	10 mg–20 mg	100 mcg–300 mcg
Frequency	1x daily	2x daily
Cycle Length	1–2 weeks	8–12 weeks
Route	intramuscular	subcutaneous
Mechanism	Contains a mixture of neuropeptides and amino acids that support neuronal metabolism, provide neuroprotection, and enhance synaptic transmission. Specific mechanisms not fully characterized.	Acts as a ghrelin mimetic, binding to the ghrelin receptor (GHS-R) in the pituitary to stimulate GH release. Highly selective with minimal effect on other hormones.
Typical Dosage	Clinical protocols: 10mg intramuscularly once daily for 10-20 days. May be repeated after 3-6 month interval.	Typical dosing ranges from 200-300mcg administered 2-3 times daily, often combined with CJC-1295.
Administration	Intramuscular injection. Comes as lyophilized powder requiring reconstitution. Treatment given in courses rather than continuously.	Subcutaneous injection. Best results when administered fasted or before sleep. Often stacked with GHRH peptides.
Side Effects	Generally well-tolerated. May cause injection site reactions or mild allergic responses in sensitive individuals.	Generally well-tolerated. May cause mild headaches, lightheadedness, or increased hunger initially.
Best For	Recovery & Healing Cognitive Performance	Muscle Growth Fat Loss Recovery & Healing Sleep Quality