Cortexin vs Hexarelin

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Cortexin

Cortexin is a polypeptide complex derived from pig brain cortex, used clinically in Russia and Eastern Europe for neurological conditions including stroke recovery, traumatic brain injury, and cognitive decline.

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Hexarelin

Hexarelin is a potent synthetic hexapeptide growth hormone secretagogue. It provides the strongest GH release among GHRPs but is associated with rapid desensitization of receptors.

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Side-by-Side Comparison

Aspect	Cortexin	Hexarelin
Dose Range	10 mg–20 mg	100 mcg–300 mcg
Frequency	1x daily	2x daily
Cycle Length	1–2 weeks	8–12 weeks
Route	intramuscular	subcutaneous
Mechanism	Contains a mixture of neuropeptides and amino acids that support neuronal metabolism, provide neuroprotection, and enhance synaptic transmission. Specific mechanisms not fully characterized.	Acts as a ghrelin mimetic with high potency at the GHS receptor. Provides powerful GH release but receptor desensitization occurs faster than with other GHRPs, requiring cycling.
Typical Dosage	Clinical protocols: 10mg intramuscularly once daily for 10-20 days. May be repeated after 3-6 month interval.	Typical dosing: 100-200mcg administered 2-3 times daily for 4-6 weeks, followed by an equal off period to allow receptor resensitization.
Administration	Intramuscular injection. Comes as lyophilized powder requiring reconstitution. Treatment given in courses rather than continuously.	Subcutaneous injection. Cycling is essential to maintain effectiveness. Often used in short bursts rather than continuous protocols.
Side Effects	Generally well-tolerated. May cause injection site reactions or mild allergic responses in sensitive individuals.	Water retention, cortisol and prolactin increase, hunger (moderate), tingling, and potential blood pressure effects.
Best For	Recovery & Healing Cognitive Performance	Muscle Growth Recovery & Healing