AOD-9604 vs MOTS-c

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

AOD-9604

AOD-9604 is a modified fragment of human growth hormone (HGH fragment 176-191). It was developed to have the fat-reducing effects of growth hormone without the adverse effects on blood sugar or growth.

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MOTS-c

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide that plays a key role in metabolic regulation and has emerged as a significant longevity research target.

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Side-by-Side Comparison

Aspect	AOD-9604	MOTS-c
Dose Range	300 mcg–500 mcg	5 mg–10 mg
Frequency	1x daily	Less than daily
Cycle Length	12–24 weeks	8–12 weeks
Route	subcutaneous	subcutaneous
Mechanism	Stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat accumulation) without affecting blood sugar or growth. Works specifically on adipose tissue through a mechanism independent of GH receptors.	Activates AMPK pathway, enhances glucose uptake in skeletal muscle, improves insulin sensitivity, and regulates mitochondrial function. Acts as a metabolic hormone affecting whole-body energy homeostasis.
Typical Dosage	Research dosing typically ranges from 250-500mcg daily, often split into morning and afternoon doses. Some protocols use higher doses up to 1mg.	Research protocols typically use 5-10mg administered subcutaneously several times per week. Optimal dosing not yet established.
Administration	Subcutaneous injection, typically in the abdominal area. Best administered on an empty stomach. Can be combined with exercise for enhanced effects.	Subcutaneous injection. Often combined with exercise protocols as it enhances exercise capacity and metabolic adaptation.
Side Effects	Generally well-tolerated. May cause headaches, injection site reactions, or temporary lethargy. Does not affect blood glucose like full GH.	Limited human data. Animal studies show good tolerability. May affect energy levels and exercise performance.
Best For	Fat Loss	Muscle Growth Fat Loss Anti-Aging & Longevity