AOD-9604 vs IGF-1 LR3

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

AOD-9604

AOD-9604 is a modified fragment of human growth hormone (HGH fragment 176-191). It was developed to have the fat-reducing effects of growth hormone without the adverse effects on blood sugar or growth.

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IGF-1 LR3

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified version of IGF-1 with extended half-life and enhanced potency. The modifications prevent binding to IGF binding proteins, increasing bioavailability.

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Side-by-Side Comparison

Aspect	AOD-9604	IGF-1 LR3
Dose Range	300 mcg–500 mcg	20 mcg–100 mcg
Frequency	1x daily	1x daily
Cycle Length	12–24 weeks	4–6 weeks
Route	subcutaneous	subcutaneous
Mechanism	Stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat accumulation) without affecting blood sugar or growth. Works specifically on adipose tissue through a mechanism independent of GH receptors.	Binds to IGF-1 receptors to promote protein synthesis, muscle growth, and fat metabolism. The LR3 modification (13 amino acid extension and arginine substitution) extends half-life from minutes to 20-30 hours.
Typical Dosage	Research dosing typically ranges from 250-500mcg daily, often split into morning and afternoon doses. Some protocols use higher doses up to 1mg.	Research protocols typically use 20-100mcg daily, often divided into multiple injections or administered bilaterally to target muscles.
Administration	Subcutaneous injection, typically in the abdominal area. Best administered on an empty stomach. Can be combined with exercise for enhanced effects.	Intramuscular injection (site-specific growth) or subcutaneous for systemic effects. Often cycled 4-6 weeks on, equal time off.
Side Effects	Generally well-tolerated. May cause headaches, injection site reactions, or temporary lethargy. Does not affect blood glucose like full GH.	Hypoglycemia, joint pain, water retention, potential jaw/hand growth with extended use, and injection site reactions.
Best For	Fat Loss	Muscle Growth Fat Loss Recovery & Healing