ANP (Atrial Natriuretic Peptide) vs TB-500

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

ANP (Atrial Natriuretic Peptide)

ANP is a cardiac hormone released by atrial myocytes in response to stretch. It promotes natriuresis, diuresis, and vasodilation, playing key roles in blood pressure and fluid regulation.

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TB-500

Thymosin Beta-4 (TB-500) is a naturally occurring peptide present in almost all human and animal cells. It plays a crucial role in tissue repair and regeneration.

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Side-by-Side Comparison

Aspect	ANP (Atrial Natriuretic Peptide)	TB-500
Dose Range	25 mcg–100 mcg	2 mg–2.5 mg
Frequency	1x daily	Less than daily
Cycle Length	1–4 weeks	4–8 weeks
Route	subcutaneous	subcutaneous
Mechanism	Binds to natriuretic peptide receptors (NPR-A) to activate guanylyl cyclase, producing cGMP. This leads to vasodilation, increased kidney filtration, and inhibition of the renin-angiotensin-aldosterone system.	TB-500 promotes cell migration and differentiation, regulates actin (a cell-building protein), and reduces inflammation. It supports the formation of new blood vessels and wound healing.
Typical Dosage	Clinical use: Carperitide (recombinant ANP) used in Japan for acute heart failure at 0.1mcg/kg/min IV infusion.	Research protocols typically use 2-2.5mg twice weekly during the loading phase, followed by maintenance dosing of 2mg every 2 weeks.
Administration	Intravenous infusion only for clinical applications. Short half-life (~2 minutes) requires continuous administration.	Administered via subcutaneous or intramuscular injection. Some protocols suggest injection near injury sites.
Side Effects	Hypotension (dose-limiting), headache, nausea, and potential arrhythmias at high doses.	May cause temporary fatigue, headache, or localized irritation at injection sites.
Best For	Recovery & Healing	Muscle Growth Recovery & Healing