ANP (Atrial Natriuretic Peptide)
ANP is a cardiac hormone released by atrial myocytes in response to stretch. It promotes natriuresis, diuresis, and vasodilation, playing key roles in blood pressure and fluid regulation.
Mechanism of Action
Binds to natriuretic peptide receptors (NPR-A) to activate guanylyl cyclase, producing cGMP. This leads to vasodilation, increased kidney filtration, and inhibition of the renin-angiotensin-aldosterone system.
Dosage Overview
Dose Range
25 mcg – 100 mcg
Route
subcutaneous
Frequency
1x daily
Cycle Length
1–4 weeks
Reconstitution
Typical Dosage (Research)
Clinical use: Carperitide (recombinant ANP) used in Japan for acute heart failure at 0.1mcg/kg/min IV infusion.
Intravenous infusion only for clinical applications. Short half-life (~2 minutes) requires continuous administration.
Considerations for Men & Women
Women: Atrial natriuretic peptide — endogenous levels differ between sexes. Women generally have lower baseline ANP levels. Estrogen influences ANP receptor sensitivity. Exogenous use is primarily clinical/research.
Men: Higher baseline ANP levels than women. Used in clinical research for heart failure. No sex-specific dosing for research protocols.
Individual responses vary. These notes reflect general trends from research literature and are not medical advice.
Quick Calculator
Quick Calculator
Concentration: 1,000 mcg/ml
Volume to inject: 0.03 ml
Syringe units (U-100): 2.5 units
Pre-filled with ANP (Atrial Natriuretic Peptide) defaults. Adjust values as needed.
Side Effects & Risks
Hypotension (dose-limiting), headache, nausea, and potential arrhythmias at high doses.
Significant hypotension risk. Requires careful monitoring. Not widely approved outside Japan.
Who Uses ANP (Atrial Natriuretic Peptide)
Heart failure patients (in Japan), cardiovascular researchers, those studying natriuretic peptide system.
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