ANP (Atrial Natriuretic Peptide) vs Cortexin

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

ANP (Atrial Natriuretic Peptide)

ANP is a cardiac hormone released by atrial myocytes in response to stretch. It promotes natriuresis, diuresis, and vasodilation, playing key roles in blood pressure and fluid regulation.

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Cortexin

Cortexin is a polypeptide complex derived from pig brain cortex, used clinically in Russia and Eastern Europe for neurological conditions including stroke recovery, traumatic brain injury, and cognitive decline.

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Side-by-Side Comparison

Aspect	ANP (Atrial Natriuretic Peptide)	Cortexin
Dose Range	25 mcg–100 mcg	10 mg–20 mg
Frequency	1x daily	1x daily
Cycle Length	1–4 weeks	1–2 weeks
Route	subcutaneous	intramuscular
Mechanism	Binds to natriuretic peptide receptors (NPR-A) to activate guanylyl cyclase, producing cGMP. This leads to vasodilation, increased kidney filtration, and inhibition of the renin-angiotensin-aldosterone system.	Contains a mixture of neuropeptides and amino acids that support neuronal metabolism, provide neuroprotection, and enhance synaptic transmission. Specific mechanisms not fully characterized.
Typical Dosage	Clinical use: Carperitide (recombinant ANP) used in Japan for acute heart failure at 0.1mcg/kg/min IV infusion.	Clinical protocols: 10mg intramuscularly once daily for 10-20 days. May be repeated after 3-6 month interval.
Administration	Intravenous infusion only for clinical applications. Short half-life (~2 minutes) requires continuous administration.	Intramuscular injection. Comes as lyophilized powder requiring reconstitution. Treatment given in courses rather than continuously.
Side Effects	Hypotension (dose-limiting), headache, nausea, and potential arrhythmias at high doses.	Generally well-tolerated. May cause injection site reactions or mild allergic responses in sensitive individuals.
Best For	Recovery & Healing	Recovery & Healing Cognitive Performance