Vasopressin

FDA approved

Vasopressin (Vasostrict) is the natural 9-amino acid antidiuretic hormone. Its FDA-approved injectable form is used to raise blood pressure in adults with shock that does not respond to fluids and other vasopressors.

At a glance

Where it acts: Heart & blood
Regulatory status: FDA approvedApproved by the U.S. FDA for at least one medical use.

Mechanism of Action

Vasopressin activates V1 receptors on blood vessel smooth muscle, causing vasoconstriction and raising blood pressure. It also acts on V2 receptors in the kidney to increase water reabsorption.

Typical Dosage (Research)

Prescription-only medicine. Dosing is set by a physician according to the FDA-approved label and the condition being treated.

Side Effects & Risks

Low sodium, reduced blood flow to fingers, gut or heart, and irregular heart rhythms.

Ischemia of the heart, gut or limbs from excessive vasoconstriction, and dangerous drops in sodium.

Who Uses Vasopressin

Critically ill adults with vasodilatory shock (e.g. septic shock), in intensive care.