Setmelanotide Dosage Guide
Complete guide to Setmelanotide dosing protocols, administration methods, and safety considerations for research purposes.
Dosage Overview
Dose per Injection
1 mg – 3 mg
Frequency
Once per day
Route
subcutaneous
Cycle Length
12–52 weeks
Reconstitution
Vial Size
5 mg
BAC Water
2.0 ml
Concentration
2,500 mcg/ml
Detailed Dosage Information
Adults
Start 2mg daily, titrate based on tolerability up to 3mg daily.
Pediatrics (6+)
Weight-based dosing starting at 1mg daily.
Administration Method
Subcutaneous injection once daily. Requires genetic testing to confirm eligible mutations before prescribing.
Research Use Only: All dosage ranges and calculations are derived from published research literature and are provided for educational purposes. These are not prescriptions or medical recommendations. Consult a healthcare professional before any use.
Concentration: 2.5 mg/ml
Volume to inject: 0.800 ml
Syringe units: 80.0 units
U-100 insulin syringe (100 units = 1 ml). Verify dose with a clinician before injecting.
Pre-filled with Setmelanotide defaults. Adjust values as needed.
Side Effects to Monitor
Injection site reactions, skin hyperpigmentation, spontaneous penile erections, depression, and suicidal ideation (boxed warning). GI effects less common than GLP-1s.
Safety Considerations & Risks
Boxed warning for depression and suicidal ideation - requires monitoring. May cause sexual adverse reactions. Only for genetically confirmed obesity.