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Plecanatide peptide vial

Plecanatide

FDA approved

Plecanatide (Trulance) is a 16-amino acid analog of the natural gut hormone uroguanylin, approved by the FDA in 2017 for chronic idiopathic constipation and IBS-C.

At a glance

Where it acts
Digestive & weight
Regulatory status
FDA approvedApproved by the U.S. FDA for at least one medical use.

Mechanism of Action

Like uroguanylin, plecanatide activates guanylate cyclase-C receptors in the upper small intestine in a pH-sensitive way, increasing cyclic GMP and fluid secretion into the gut, which softens stool and speeds transit.

Typical Dosage (Research)

Prescription-only medicine. Dosing is set by a physician according to the FDA-approved label and the condition being treated.

Side Effects & Risks

Diarrhea is the most common side effect; others include abdominal distension, flatulence and sinusitis.

Contraindicated in children under 6 because of dehydration risk, and in known or suspected mechanical bowel obstruction. Stop if severe diarrhea occurs.

Who Uses Plecanatide

Adults with chronic idiopathic constipation or IBS-C.