Cosyntropin

FDA approved

Cosyntropin (Cortrosyn) is a synthetic peptide made of the first 24 amino acids of ACTH. It is used as a diagnostic test, the ACTH stimulation test, to check whether the adrenal glands can make cortisol.

At a glance

Where it acts: Hormones & metabolism
Regulatory status: FDA approvedApproved by the U.S. FDA for at least one medical use.

Mechanism of Action

Cosyntropin contains the portion of ACTH responsible for its full biological activity. It binds adrenal melanocortin-2 receptors and stimulates cortisol release; a low cortisol rise after injection indicates adrenal insufficiency.

Typical Dosage (Research)

Prescription-only medicine. Dosing is set by a physician according to the FDA-approved label and the condition being treated.

Side Effects & Risks

Usually well tolerated as a single dose; flushing, nausea or mild allergic reactions can occur.

Rare hypersensitivity reactions. Results can be affected by recent steroid use or estrogen therapy.

Who Uses Cosyntropin

Patients being tested for adrenal insufficiency (e.g. Addison's disease or secondary adrenal insufficiency).