Corticotropin (ACTH)

FDA approved

Corticotropin, or ACTH (Acthar Gel and Purified Cortrophin Gel), is a 39-amino acid pituitary hormone approved for infantile spasms and as a treatment for flares of several inflammatory and autoimmune diseases, including multiple sclerosis.

At a glance

Where it acts: Hormones & metabolism
Regulatory status: FDA approvedApproved by the U.S. FDA for at least one medical use.

Mechanism of Action

ACTH binds melanocortin-2 receptors in the adrenal cortex, stimulating the release of cortisol and other corticosteroids. It also binds other melanocortin receptors, which may contribute anti-inflammatory effects independent of cortisol.

Typical Dosage (Research)

Prescription-only medicine. Dosing is set by a physician according to the FDA-approved label and the condition being treated.

Side Effects & Risks

Effects similar to corticosteroids: fluid retention, high blood pressure, high blood sugar, mood changes and weight gain.

Increased infection risk, adrenal suppression, stomach ulcers, osteoporosis with long-term use, and masking of infection symptoms. Expensive compared with steroid alternatives.

Who Uses Corticotropin (ACTH)

Infants with infantile spasms; adults with MS relapses, certain rheumatic, kidney or eye inflammatory conditions.