Syn-Ake vs SHLP2
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Syn-Ake
Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate) is a synthetic tripeptide that mimics the effect of Waglerin-1, a peptide found in Temple Viper venom. It's used in cosmetics for anti-wrinkle effects.
Full details →SHLP2
SHLP2 (Small Humanin-Like Peptide 2) is a mitochondrial-derived peptide similar to humanin. It has shown insulin-sensitizing and cytoprotective effects in research, with potential metabolic benefits.
Full details →Side-by-Side Comparison
| Aspect | Syn-Ake | SHLP2 |
|---|---|---|
| Mechanism | Acts as a competitive antagonist at the nicotinic acetylcholine receptor, reducing muscle contractions similar to Botox but through a different mechanism. Provides muscle-relaxing effects when applied topically. | Enhances insulin sensitivity and glucose uptake. Provides cytoprotective effects similar to humanin. May act through similar but distinct receptor pathways. |
| Typical Dosage | Topical: 1-4% concentration in serums or creams. Applied 1-2 times daily to target areas like forehead and crow's feet. | Research compound with doses in the microgram to low milligram range studied in animal models. Human dosing not established. |
| Administration | Topical application only. Should be applied to clean skin. Often combined with other anti-aging peptides for synergistic effects. | Subcutaneous or intraperitoneal injection in research settings. Various SHLP analogs (1-6) have different properties. |
| Side Effects | Generally well-tolerated topically. Rare reports of mild skin irritation or sensitivity. | Limited data. Animal studies suggest good tolerability. May affect glucose metabolism. |
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