Pinealon vs Selank
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
Pinealon
Pinealon is a short synthetic peptide developed from research on the pineal gland. It has shown neuroprotective and cognitive-enhancing properties in animal studies.
Full details →Selank
Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin. Developed in Russia for anxiety and cognitive enhancement.
Full details →Side-by-Side Comparison
| Aspect | Pinealon | Selank |
|---|---|---|
| Dose Range | 5 mg–10 mg | 300 mcg–900 mcg |
| Frequency | 1x daily | 2x daily |
| Cycle Length | 1–2 weeks | 2–4 weeks |
| Route | subcutaneous | intranasal |
| Mechanism | Penetrates cell membranes and interacts with DNA to regulate gene expression related to neuronal survival and function. May support pineal gland function and melatonin production. | Modulates the expression of brain-derived neurotrophic factor (BDNF) and affects serotonin and norepinephrine systems. Has immunomodulatory and anxiolytic properties. |
| Typical Dosage | Typical dosing: 10-20mg daily, taken in divided doses. Often used in cycles of 10-20 days. | Intranasal administration: 250-500mcg 2-3 times daily. Subcutaneous: 250-500mcg daily. |
| Administration | Can be taken orally (capsules) or sublingually. Best absorbed on an empty stomach. Often combined with other neuroprotective peptides. | Most commonly administered intranasally for cognitive effects. Can also be injected subcutaneously. |
| Side Effects | Generally well-tolerated. Limited reported side effects. May affect sleep patterns initially. | Generally well-tolerated. Some users report mild fatigue or nasal irritation with intranasal use. |
| Best For |
What They Have in Common
Pinealon, Selank are both commonly used for:
Key Differences
Unique to Pinealon:
Which Has Stronger Evidence?
- Cognitive Performance: Selank has stronger research support.
| Goal | Pinealon | Selank |
|---|---|---|
| Cognitive Performance | low | high |
Key Studies
Pinealon
- [Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].
Advances in gerontology = Uspekhi gerontologii, 2015
- [Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].
Advances in gerontology = Uspekhi gerontologii, 2014
- Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.
International journal of clinical and experimental medicine, 2012
Selank
- Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Bulletin of experimental biology and medicine, 2022
- The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
Current reviews in clinical and experimental pharmacology, 2021
- Functional Connectomic Approach to Studying Selank and Semax Effects.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2020
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