LL-37 (Cathelicidin) vs Teriparatide

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

LL-37 (Cathelicidin)

LL-37 is the only human cathelicidin antimicrobial peptide. It plays crucial roles in innate immunity and has shown diverse biological activities including antimicrobial, immunomodulatory, and wound healing properties.

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Teriparatide

Teriparatide (Forteo) is recombinant human parathyroid hormone (1-34), FDA-approved for osteoporosis treatment. It's unique among osteoporosis drugs in that it stimulates new bone formation.

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Side-by-Side Comparison

Aspect	LL-37 (Cathelicidin)	Teriparatide
Dose Range	500 mcg–1.6 mg	20 mcg
Frequency	1x daily	1x daily
Cycle Length	2–4 weeks	52–104 weeks
Route	topical	subcutaneous
Mechanism	Disrupts bacterial membranes, neutralizes endotoxins, modulates immune cell function, and promotes wound healing. Has both direct antimicrobial and immunomodulatory effects.	Intermittent PTH exposure paradoxically stimulates osteoblasts more than osteoclasts, resulting in net bone formation. Continuous exposure would cause bone loss, but pulsatile dosing builds bone.
Typical Dosage	Research protocols vary widely. Typical ranges: 50-200mcg administered subcutaneously 2-3 times weekly. Some protocols use higher doses for acute infections.	20mcg subcutaneously once daily. Maximum treatment duration of 2 years due to theoretical osteosarcoma risk from rat studies.
Administration	Subcutaneous injection. Can cause significant injection site reactions. Often used in conjunction with other immune-supporting protocols.	Subcutaneous injection in thigh or abdomen once daily. Delivered via multi-dose pen. Should sit or lie down after injection due to orthostatic hypotension risk.
Side Effects	Injection site pain and reactions are common. May cause flu-like symptoms, temporary fatigue, or immune activation responses.	Orthostatic hypotension, leg cramps, nausea, dizziness, headache, and injection site reactions. Transient hypercalcemia possible.
Best For	Recovery & Healing	Recovery & Healing