HGH Fragment 176-191 vs Palmitoyl Tetrapeptide-7

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

HGH Fragment 176-191

HGH Fragment 176-191 is the fat-reducing portion of the growth hormone molecule. Unlike AOD-9604 (which has an additional tyrosine), this is the exact fragment of HGH responsible for lipolytic effects.

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Palmitoyl Tetrapeptide-7

Palmitoyl Tetrapeptide-7 is an anti-inflammatory peptide that reduces IL-6 secretion. Combined with Palmitoyl Tripeptide-1, it forms Matrixyl 3000, addressing both collagen production and inflammation.

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Side-by-Side Comparison

AspectHGH Fragment 176-191Palmitoyl Tetrapeptide-7
MechanismMimics the lipolytic region of growth hormone, stimulating fat breakdown and inhibiting lipogenesis without affecting blood sugar or promoting growth. Works independently of GH receptors.Suppresses interleukin-6 (IL-6) production, reducing inflammation that contributes to skin aging. The anti-inflammatory effect complements collagen-stimulating peptides.
Typical DosageTypical dosing: 250-500mcg daily, often split into 2-3 doses. Usually administered on empty stomach, often with fasted cardio.Topical: Usually combined with Palmitoyl Tripeptide-1 at similar concentrations (2-4%) in the Matrixyl 3000 complex.
AdministrationSubcutaneous injection. Best results when used fasted and combined with exercise. Avoid eating for 30 minutes post-injection.Topical application with other anti-aging actives. The palmitoyl group enhances delivery into the skin.
Side EffectsGenerally well-tolerated. May cause injection site irritation, temporary lethargy, or headache. Does not affect blood glucose significantly.Excellent tolerability profile. Anti-inflammatory properties may actually soothe sensitive skin.
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Key Differences

Unique to HGH Fragment 176-191:

Unique to Palmitoyl Tetrapeptide-7:

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