GHRP-2 vs SHLP2
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
GHRP-2
Growth Hormone Releasing Peptide 2 (GHRP-2) is considered one of the most potent GHRPs available. It provides strong GH release with moderate hunger increase compared to GHRP-6.
Full details →SHLP2
SHLP2 (Small Humanin-Like Peptide 2) is a mitochondrial-derived peptide similar to humanin. It has shown insulin-sensitizing and cytoprotective effects in research, with potential metabolic benefits.
Full details →Side-by-Side Comparison
| Aspect | GHRP-2 | SHLP2 |
|---|---|---|
| Dose Range | 100 mcg–300 mcg | 1 mg–5 mg |
| Frequency | 3x daily | 1x daily |
| Cycle Length | 8–12 weeks | 4–8 weeks |
| Route | subcutaneous | subcutaneous |
| Mechanism | Binds to the ghrelin receptor (GHS-R) to stimulate GH release from the pituitary. Also has some direct effects on the hypothalamus. Causes less appetite increase than GHRP-6. | Enhances insulin sensitivity and glucose uptake. Provides cytoprotective effects similar to humanin. May act through similar but distinct receptor pathways. |
| Typical Dosage | Typical dosing: 100-300mcg administered 2-3 times daily. Often stacked with GHRH peptides for enhanced GH release. | Research compound with doses in the microgram to low milligram range studied in animal models. Human dosing not established. |
| Administration | Subcutaneous injection on an empty stomach. Can be used at bedtime to enhance natural GH pulse during sleep. | Subcutaneous or intraperitoneal injection in research settings. Various SHLP analogs (1-6) have different properties. |
| Side Effects | Moderate hunger increase, water retention, potential prolactin and cortisol elevation (less than GHRP-6), tingling sensations. | Limited data. Animal studies suggest good tolerability. May affect glucose metabolism. |
| Best For |
What They Have in Common
GHRP-2, SHLP2 are both commonly used for:
Key Differences
Unique to GHRP-2:
Unique to SHLP2:
Which Has Stronger Evidence?
- Fat Loss: GHRP-2 has stronger research support.
| Goal | GHRP-2 | SHLP2 |
|---|---|---|
| Fat Loss | medium | low |
Key Studies
GHRP-2
- On the road of dried blood spot sampling for antidoping tests: Detection of GHRP-2 abuse.
Drug testing and analysis, 2021
- Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation.
PloS one, 2016
- Ghrelin receptor agonist, GHRP-2, produces antinociceptive effects at the supraspinal level via the opioid receptor in mice.
Peptides, 2014
SHLP2
- Mitochondrial Peptide SHLP2 Limits Poly(I: C)-Induced Alveolar Epithelial Injury by Modulating Redox, Apoptotic, Inflammatory, and Inflammasome Responses.
Cytotechnology, 2026
- SHLP2 restores pre-osteoblastic cells against oxidative stress-induced inflammaging.
Scientific reports, 2025
- SHLP2 alleviates allergic asthma by inhibiting ETV5/GSDMD signaling pathway-mediated pyroptosis.
Cellular signalling, 2025
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