Follistatin vs TB-500

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Follistatin

Follistatin is a glycoprotein that inhibits myostatin, the protein responsible for limiting muscle growth. By blocking myostatin, follistatin can theoretically allow for increased muscle development beyond natural limits.

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TB-500

Thymosin Beta-4 (TB-500) is a naturally occurring peptide present in almost all human and animal cells. It plays a crucial role in tissue repair and regeneration.

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Side-by-Side Comparison

Aspect	Follistatin	TB-500
Dose Range	50 mcg–100 mcg	2 mg–2.5 mg
Frequency	1x daily	Less than daily
Cycle Length	2–4 weeks	4–8 weeks
Route	subcutaneous	subcutaneous
Mechanism	Binds to and neutralizes myostatin and activin, both of which are negative regulators of muscle mass. This removes the natural brake on muscle growth, allowing for enhanced hypertrophy.	TB-500 promotes cell migration and differentiation, regulates actin (a cell-building protein), and reduces inflammation. It supports the formation of new blood vessels and wound healing.
Typical Dosage	Research protocols typically use 100-300mcg daily, though optimal dosing is not well established. Gene therapy approaches have also been studied.	Research protocols typically use 2-2.5mg twice weekly during the loading phase, followed by maintenance dosing of 2mg every 2 weeks.
Administration	Subcutaneous injection. Different isoforms exist (FS344, FS315) with varying properties. Requires careful sourcing due to complexity.	Administered via subcutaneous or intramuscular injection. Some protocols suggest injection near injury sites.
Side Effects	Limited human data. Theoretical concerns about effects on other organs where activin signaling is important.	May cause temporary fatigue, headache, or localized irritation at injection sites.
Best For	Muscle Growth	Muscle Growth Recovery & Healing