Epithalamin vs Palmitoyl Tetrapeptide-7

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Epithalamin

Epithalamin is a natural peptide extract from the pineal gland. It is the precursor compound from which the synthetic Epitalon was derived. Known for anti-aging and telomerase-activating properties.

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Palmitoyl Tetrapeptide-7

Palmitoyl Tetrapeptide-7 is an anti-inflammatory peptide that reduces IL-6 secretion. Combined with Palmitoyl Tripeptide-1, it forms Matrixyl 3000, addressing both collagen production and inflammation.

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Side-by-Side Comparison

AspectEpithalaminPalmitoyl Tetrapeptide-7
MechanismSimilar to Epitalon, it stimulates telomerase production and may help maintain telomere length. Also regulates melatonin synthesis and circadian rhythms.Suppresses interleukin-6 (IL-6) production, reducing inflammation that contributes to skin aging. The anti-inflammatory effect complements collagen-stimulating peptides.
Typical DosageResearch dosing: 10-20mg daily for 10-20 day cycles. Often administered 1-3 times per year in long-term protocols.Topical: Usually combined with Palmitoyl Tripeptide-1 at similar concentrations (2-4%) in the Matrixyl 3000 complex.
AdministrationIntramuscular or subcutaneous injection. Natural extract may have more variable composition than synthetic Epitalon.Topical application with other anti-aging actives. The palmitoyl group enhances delivery into the skin.
Side EffectsGenerally well-tolerated. May affect sleep patterns. Less characterized than synthetic Epitalon.Excellent tolerability profile. Anti-inflammatory properties may actually soothe sensitive skin.
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Key Differences

Unique to Epithalamin:

Unique to Palmitoyl Tetrapeptide-7:

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