Cortexin vs TB-500

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Cortexin

Cortexin is a polypeptide complex derived from pig brain cortex, used clinically in Russia and Eastern Europe for neurological conditions including stroke recovery, traumatic brain injury, and cognitive decline.

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TB-500

Thymosin Beta-4 (TB-500) is a naturally occurring peptide present in almost all human and animal cells. It plays a crucial role in tissue repair and regeneration.

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Side-by-Side Comparison

Aspect	Cortexin	TB-500
Dose Range	10 mg–20 mg	2 mg–2.5 mg
Frequency	1x daily	Less than daily
Cycle Length	1–2 weeks	4–8 weeks
Route	intramuscular	subcutaneous
Mechanism	Contains a mixture of neuropeptides and amino acids that support neuronal metabolism, provide neuroprotection, and enhance synaptic transmission. Specific mechanisms not fully characterized.	TB-500 promotes cell migration and differentiation, regulates actin (a cell-building protein), and reduces inflammation. It supports the formation of new blood vessels and wound healing.
Typical Dosage	Clinical protocols: 10mg intramuscularly once daily for 10-20 days. May be repeated after 3-6 month interval.	Research protocols typically use 2-2.5mg twice weekly during the loading phase, followed by maintenance dosing of 2mg every 2 weeks.
Administration	Intramuscular injection. Comes as lyophilized powder requiring reconstitution. Treatment given in courses rather than continuously.	Administered via subcutaneous or intramuscular injection. Some protocols suggest injection near injury sites.
Side Effects	Generally well-tolerated. May cause injection site reactions or mild allergic responses in sensitive individuals.	May cause temporary fatigue, headache, or localized irritation at injection sites.
Best For	Recovery & Healing Cognitive Performance	Muscle Growth Recovery & Healing