Cortexin vs Selank

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Cortexin

Cortexin is a polypeptide complex derived from pig brain cortex, used clinically in Russia and Eastern Europe for neurological conditions including stroke recovery, traumatic brain injury, and cognitive decline.

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Selank

Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin. Developed in Russia for anxiety and cognitive enhancement.

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Side-by-Side Comparison

Aspect	Cortexin	Selank
Dose Range	10 mg–20 mg	300 mcg–900 mcg
Frequency	1x daily	2x daily
Cycle Length	1–2 weeks	2–4 weeks
Route	intramuscular	intranasal
Mechanism	Contains a mixture of neuropeptides and amino acids that support neuronal metabolism, provide neuroprotection, and enhance synaptic transmission. Specific mechanisms not fully characterized.	Modulates the expression of brain-derived neurotrophic factor (BDNF) and affects serotonin and norepinephrine systems. Has immunomodulatory and anxiolytic properties.
Typical Dosage	Clinical protocols: 10mg intramuscularly once daily for 10-20 days. May be repeated after 3-6 month interval.	Intranasal administration: 250-500mcg 2-3 times daily. Subcutaneous: 250-500mcg daily.
Administration	Intramuscular injection. Comes as lyophilized powder requiring reconstitution. Treatment given in courses rather than continuously.	Most commonly administered intranasally for cognitive effects. Can also be injected subcutaneously.
Side Effects	Generally well-tolerated. May cause injection site reactions or mild allergic responses in sensitive individuals.	Generally well-tolerated. Some users report mild fatigue or nasal irritation with intranasal use.
Best For	Recovery & Healing Cognitive Performance	Cognitive Performance