Cortexin vs LL-37 (Cathelicidin)

A detailed comparison to help you understand the differences and choose the right peptide for your research goals.

Cortexin

Cortexin is a polypeptide complex derived from pig brain cortex, used clinically in Russia and Eastern Europe for neurological conditions including stroke recovery, traumatic brain injury, and cognitive decline.

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LL-37 (Cathelicidin)

LL-37 is the only human cathelicidin antimicrobial peptide. It plays crucial roles in innate immunity and has shown diverse biological activities including antimicrobial, immunomodulatory, and wound healing properties.

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Side-by-Side Comparison

Aspect	Cortexin	LL-37 (Cathelicidin)
Dose Range	10 mg–20 mg	500 mcg–1.6 mg
Frequency	1x daily	1x daily
Cycle Length	1–2 weeks	2–4 weeks
Route	intramuscular	topical
Mechanism	Contains a mixture of neuropeptides and amino acids that support neuronal metabolism, provide neuroprotection, and enhance synaptic transmission. Specific mechanisms not fully characterized.	Disrupts bacterial membranes, neutralizes endotoxins, modulates immune cell function, and promotes wound healing. Has both direct antimicrobial and immunomodulatory effects.
Typical Dosage	Clinical protocols: 10mg intramuscularly once daily for 10-20 days. May be repeated after 3-6 month interval.	Research protocols vary widely. Typical ranges: 50-200mcg administered subcutaneously 2-3 times weekly. Some protocols use higher doses for acute infections.
Administration	Intramuscular injection. Comes as lyophilized powder requiring reconstitution. Treatment given in courses rather than continuously.	Subcutaneous injection. Can cause significant injection site reactions. Often used in conjunction with other immune-supporting protocols.
Side Effects	Generally well-tolerated. May cause injection site reactions or mild allergic responses in sensitive individuals.	Injection site pain and reactions are common. May cause flu-like symptoms, temporary fatigue, or immune activation responses.
Best For	Recovery & Healing Cognitive Performance	Recovery & Healing