BNP (B-type Natriuretic Peptide)

BNP is a cardiac neurohormone released primarily by ventricles in response to volume/pressure overload. It's a major biomarker for heart failure and has therapeutic applications as nesiritide.

Mechanism of Action

Similar to ANP - activates NPR-A receptors to produce vasodilation, natriuresis, and RAAS suppression. Released in response to ventricular wall stress.

Typical Dosage (Research)

Nesiritide (recombinant BNP): 2mcg/kg IV bolus followed by 0.01mcg/kg/min continuous infusion for acute decompensated heart failure.

Intravenous administration only. Used in acute care settings for heart failure. BNP levels also used diagnostically.

Side Effects & Risks

Hypotension (common and dose-limiting), headache, nausea, and potential renal function worsening in some patients.

Controversial efficacy data. Concerns about renal effects and mortality in some studies led to reduced use. Requires careful hemodynamic monitoring.

Who Uses BNP (B-type Natriuretic Peptide)

Acute heart failure patients in hospital settings, cardiovascular researchers.