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Angiotensin II peptide vial

Angiotensin II

FDA approved

Angiotensin II (Giapreza) is a synthetic version of the natural 8-amino acid hormone, approved by the FDA in 2017 to raise blood pressure in adults with septic or other distributive shock.

At a glance

Where it acts
Heart & blood
Regulatory status
FDA approvedApproved by the U.S. FDA for at least one medical use.

Mechanism of Action

Angiotensin II binds AT1 receptors on blood vessel smooth muscle, causing vasoconstriction, and stimulates aldosterone and vasopressin release. Together these raise blood pressure in shock.

Typical Dosage (Research)

Prescription-only medicine. Dosing is set by a physician according to the FDA-approved label and the condition being treated.

Side Effects & Risks

Blood clots, low platelet counts, fast heart rate and fungal infections.

Arterial and venous blood clots; prophylactic anticoagulation is recommended during treatment.

Who Uses Angiotensin II

Critically ill adults with distributive shock, in intensive care.